Compact Modeling of Allosteric Multisite Proteins: Application to a Cell Size Checkpoint
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چکیده
منابع مشابه
Compact Modeling of Allosteric Multisite Proteins: Application to a Cell Size Checkpoint
We explore a framework to model the dose response of allosteric multisite phosphorylation proteins using a single auxiliary variable. This reduction can closely replicate the steady state behavior of detailed multisite systems such as the Monod-Wyman-Changeux allosteric model or rule-based models. Optimal ultrasensitivity is obtained when the activation of an allosteric protein by its individua...
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Protein functions in cells may be activated or modified by the attachment of several kinds of chemical groups. While protein phosphorylation, i.e. the attachment of a phosphoryl (PO−3 ) group, is the most studied form of protein modification, and is known to regulate the functions of many proteins, protein behavior can also be modified by nitrosylation, acetylation, methylation, etc. A protein ...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2014
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1003443